本課程之先修課程為普通化學，本課程的內容主要是依據所指定之教科書按時程授課，強調官能機的性質、命名及其轉換與反應機制的介紹。本課程為一學年分上下兩學期之課程，適合化學系的大二學生修習，涵蓋以下綱要主題。


(1) Covalent Bonding and Shapes of Molecules
Lewis model of bonding
Polar and nonpolar molecules
Valence bond model of covalent bonding
Functional groups

(2) Alkanes and Cycloalkanes
Structure and isomerism of alkanes
Conformations of alkanes
Reactions of alkanes
Sources of alkanes

(3) Stereochemistry and Chirality
Stereoisomerism and chirality
Naming stereocenters
Optical activity
The significance of chirality in the biological world

(4) Acids and Bases
Bronsted-Lowry acids and bases
Molecular structure and acidity
Lewis acids and bases

(5) Alkenes, Alkynes and Their Reactions
Structure and nomenclature
Reaction mechanisms
Electrophilic addition reactions
Radical Reactions
Nucleophilic Substitution and (83d2)-Elimination

(6) Alcohols and Thiols
Structure, properties and nomenclature
Reactions of alcohols

(7) Ethers, Sulfides, and Epoxides
Structure and nomenclature
Reactions of alcohols, ethers and epoxides

(8) NMR Spectroscopy
Nuclear magnetic resonance
Chemical shifts and signal splitting

(9) Organometallic Compounds
Organomagnesium and organolithium compounds
Gilman reagent
Carbenes and carbenoids

(10) Aldehydes and Ketones
Nomenclature of aldehydes and ketones
Synthesis of aldehydes and ketones
Nucleophilic addition to the carbon-oxygen double bond
Keto-enol tautomerism
Reactions at an (83d1)-carbon

(11) Carboxylic Acids
Structure and nomenclature
Esterification
Decarboxylation

(12) Functional Derivatives of Carboxylic Acids
Structure and nomenclature
Interconversion of functional derivatives
The Hoffman rearrangement

(13) Enolate Anions and Enamines
The aldol reaction
Claisen and Dieckmann condensations
Enamines

(14) Aromatics
Benzene and its derivatives
Reactions of benzene and its derivatives

(15) Amines
Structure, nomenclature and classification
Basicity
Reaction with acids

(16) Carbohydrates
Monosaccharides
Reactions of monosaccharides
Disaccharides and polysaccharides

評分標準：本課程將依據上課進度及時程安排進行三次考試，各占30%（包括期末考），另有作業成績占10%，學期總成績將由此加總分數來評定。考試時學生需準時參加，並且不得有作弊的行為，除了因公務或疾病原因外（需醫院證明），缺考者該次考試成績以零分計算。